Important Safety Information

• The most common adverse reaction reported is vomiting.
• Other adverse reactions reported in decreasing order of frequency are: depression/lethargy, decreased appetite, incoordination, diarrhea, itching, trembling, excessive salivation and seizures.
• Following concomitant extra label use of ivermectin with Comfortis, some dogs have experienced the following clinical signs: trembling/twitching, salivation /drooling, seizures, incoordination, excessive dilation of pupils, blindness and disorientation.
• Post approval experience continues to support the safety of Comfortis when used concurrently with heartworm preventatives according to label directions.
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